Verburg IW, Atashi A, Eslami S, Holman R, Abu-Hanna A, de Jonge E, Peek N, de Keizer NF.; Crit Care Med. 2017 Feb;45(2):e222-e231.
Objective: We systematically reviewed models to predict adult ICU length of stay.
Data Sources: We searched the Ovid EMBASE and MEDLINE databases for studies on the development or validation of ICU length of stay prediction models.
2017 Feb - Sepsis Pathophysiology, Chronic Critical Illness, and Persistent Inflammation-Immunosuppression and Catabolism Syndrome
Mira JC, Gentile LF, Mathias BJ, Efron PA, Brakenridge SC, Mohr AM, Moore FA, Moldawer LL.; Crit Care Med. 2017 Feb;45(2):253-262.
OBJECTIVES: To provide an appraisal of the evolving paradigms in the pathophysiology of sepsis and propose the evolution of a new phenotype of critically ill patients, its potential underlying mechanism, and its implications for the future of sepsis management and research.
Roberts JA, Kumar A, Lipman J.; Crit Care Med. 2017 Feb;45(2):331-336.
Drugs are key weapons that clinicians have to battle against the profound pathologies encountered in critically ill patients. Antibiotics in particular are commonly used and can improve patient outcomes dramatically. Despite this, there are strong opportunities for further reducing the persisting poor outcomes for infected critically ill patients. However, taking these next steps for improving patient care requires a new approach to antibiotic therapy.
2017 Feb - Long-Term Survival in Adults Treated With Extracorporeal Membrane Oxygenation for Respiratory Failure and Sepsis
von Bahr V, Hultman J, Eksborg S, Frenckner B, Kalzén H.; Crit Care Med. 2017 Feb;45(2):164-170.
OBJECTIVE: The use of extracorporeal membrane oxygenation in adults with respiratory failure and sepsis is steadily increasing, but the knowledge on long-term survival in this group is scarce. The aim of the present study was to investigate the 5-year survival rates and causes of late death in this group of patients.
2017 Feb - Greater Protein and Energy Intake May Be Associated With Improved Mortality in Higher Risk Critically Ill Patients: A Multicenter, Multinational Observational Study
Compher C, Chittams J, Sammarco T, Nicolo M, Heyland DK.; Crit Care Med. 2017 Feb;45(2):156-163.
OBJECTIVES: Controversy exists about the value of greater nutritional intake in critically ill patients, possibly due to varied patient nutritional risk. The objective of this study was to investigate whether clinical outcomes vary by protein or energy intake in patients with risk evaluated by the NUTrition Risk in the Critically Ill score.
2016 Dec - Lactated Ringer Is Associated With Reduced Mortality and Less Acute Kidney Injury in Critically Ill Patients: A Retrospective Cohort Analysis
Zampieri FG, Ranzani OT, Azevedo LC, Martins ID, Kellum JA, Libório AB.; Crit Care Med. 2016 Dec;44(12):2163-2170.
Objectives: To assess the impact of the percentage of fluid infused as Lactated Ringer (%LR) during the first 2 days of ICU admission in hospital mortality and occurrence of acute kidney injury.
2016 Dec - The Impact of Interventions to Improve Sleep on Delirium in the ICU: A Systematic Review and Research Framework
Flannery AH, Oyler DR, Weinhouse GL.; Crit Care Med. 2016 Dec;44(12):2231-2240
Objective : This study aimed to assess whether interventions targeted at improving sleep in the ICU were associated with reductions in ICU delirium. Secondary outcomes include duration of delirium and ICU length of stay.
2016 Dec- Protocol-Based Resuscitation Bundle to Improve Outcomes in Septic Shock Patients: Evaluation of the Michigan Health and Hospital Association Keystone Sepsis Collaborative
Thompson MP, Reeves MJ, Bogan BL, DiGiovine B, Posa PJ, Watson SR.; Crit Care Med. 2016 Dec;44(12):2123-2130.
Objectives: To evaluate the impact of a multi-ICU quality improvement collaborative implementing a protocol-based resuscitation bundle to treat septic shock patients.
2016 Dec - Patient and Organizational Factors Associated With Delays in Antimicrobial Therapy for Septic Shock
Amaral AC, Fowler RA, Pinto R, Rubenfeld GD, Ellis P, Bookatz B, Marshall JC, Martinka G, Keenan S, Laporta D, Roberts D, Kumar A; Cooperative Antimicrobial Therapy of Septic Shock Database Research Group..; Crit Care Med. 2016 Dec;44(12):2145-2153.
Objectives: To identify clinical and organizational factors associated with delays in antimicrobial therapy for septic shock.
2016 Nov - Neuromuscular Blocking Agents and Neuromuscular Dysfunction Acquired in Critical Illness: A Systematic Review and Meta-Analysis
Price DR, Mikkelsen ME, Umscheid CA, Armstrong EJ.; Crit Care Med. 2016 Nov;44(11):2070-2078.
Objective: The relationship between neuromuscular blocking agents and neuromuscular dysfunction acquired in critical illness remains unclear. We examined the association between neuromuscular blocking agents and ICU-acquired weakness, critical illness polyneuropathy, and critical illness myopathy.
2016 Nov - The Postcardiac Arrest Consult Team: Impact on Hospital Care Processes for Out-of-Hospital Cardiac Arrest Patients
Brooks SC, Scales DC, Pinto R, Dainty KN, Racz EM, Gaudio M, Amaral AC, Gray SH, Friedrich JO, Chapman M, Dorian P, Fam N, Fowler RA, Hayes CW, Baker A, Crystal E, Madan M, Rubenfeld G, Smith OM, Morrison LJ.; Crit Care Med. 2016 Nov;44(11):2037-2044.
Objective: To evaluate whether a Post-Arrest Consult Team improved care and outcomes for patients with out-of-hospital cardiac arrest.
2016 Nov - The Effect of Intraaortic Balloon Pumping Under Venoarterial Extracorporeal Membrane Oxygenation on Mortality of Cardiogenic Patients: An Analysis Using a Nationwide Inpatient Database
Aso S, Matsui H, Fushimi K, Yasunaga H.; Crit Care Med. 2016 Nov;44(11):1974-1979.
Objectives: The role of intraaortic balloon pumping combined with venoarterial extracorporeal membrane oxygenation in cardiogenic shock patients remains unknown. This study investigated the effect of intraaortic balloon pumping combined with venoarterial extracorporeal membrane oxygenation on reducing mortality of cardiogenic shock patients.
2016 Nov - Randomized Trial of Video Laryngoscopy for Endotracheal Intubation of Critically Ill Adults
Janz DR, Semler MW, Lentz RJ, Matthews DT, Assad TR, Norman BC, Keriwala RD, Ferrell BA, Noto MJ, Shaver CM, Richmond BW, Zinggeler Berg J, Rice TW; Facilitating EndotracheaL intubation by Laryngoscopy technique and apneic Oxygenation Within the ICU Investigators and the Pragmatic Critical Care Research Group..; Crit Care Med. 2016 Nov;44(11):1980-1987.
Objective: To evaluate the effect of video laryngoscopy on the rate of endotracheal intubation on first laryngoscopy attempt among critically ill adults.
Sasabuchi Y, Matsui H, Lefor AK, Fushimi K, Yasunaga H.; Crit Care Med. 2016 Jul;44(7):e464-9.
Objectives: The Surviving Sepsis Campaign Guidelines recommend stress ulcer prophylaxis for patients with severe sepsis who have bleeding risks. Although sepsis has been considered as a risk factor for gastrointestinal bleeding, the effect of stress ulcer prophylaxis has not been studied in patients with severe sepsis. Furthermore, stress ulcer prophylaxis may be associated with an increased risk of hospital-acquired pneumonia or Clostridium difficile infection. The aim of this study was to investigate the risks and benefits of stress ulcer prophylaxis for patients with severe sepsis.
2016 Jul - Impact of Initial Ventilatory Strategy in Hematological Patients With Acute Respiratory Failure: A Systematic Review and Meta-Analysis
Amado-Rodríguez L, Bernal T, López-Alonso I, Blázquez-Prieto J, García-Prieto E, Albaiceta GM.;Crit Care Med. 2016 Jul;44(7):1406-13.
Objective: Acute respiratory failure in hematological patients is related to a high mortality. Noninvasive mechanical ventilation may benefit a subset of these patients, but the overall effect on mortality and the risks derived from its failure are unclear. Our objective was to review the impact of initial ventilatory strategy on mortality and the risks related to noninvasive mechanical ventilation failure in this group of patients.
2016 Jul - Admission Hyperglycemia in Critically Ill Sepsis Patients: Association With Outcome and Host Response
van Vught LA, Wiewel MA, Klein Klouwenberg PM, Hoogendijk AJ, Scicluna BP, Ong DS, Cremer OL, Horn J, Bonten MM, Schultz MJ, van der Poll T; Molecular Diagnosis and Risk Stratification of Sepsis Consortium.; Crit Care Med. 2016 Jul;44(7):1338-46.
Objectives: To investigate whether admission hyperglycemia is associated with the presentation and/or outcome of sepsis, what the influence of hyperglycemia is on key host responses to sepsis, and whether hyperglycemia differentially affects patients with diabetes mellitus.
Barletta JF, Bruno JJ, Buckley MS, Cook DJ.; Crit Care Med. 2016 Jul;44(7):1395-405.
Objectives: Stress ulcer prophylaxis is commonly administered to critically ill patients for the prevention of clinically important stress-related mucosal bleeding from the upper gastrointestinal tract. Despite widespread incorporation of stress ulcer prophylaxis into practice around the world, questions are emerging about its indications and impact. This clinically focused article will review current controversies related to stress ulcer prophylaxis for critically ill adult patients, including bleeding frequency, risk factors, comparative efficacy, adverse effect profile, and overall cost-effectiveness of the available stress ulcer prophylaxis regimens.
2016 Jul - Dexmedetomidine for the Treatment of Hyperactive Delirium Refractory to Haloperidol in Nonintubated ICU Patients: A Nonrandomized Controlled Trial
Carrasco G, Baeza N, Cabré L, Portillo E, Gimeno G, Manzanedo D, Calizaya M.; Crit Care Med. 2016 Jul;44(7):1295-306.
Objectives: To evaluate the clinical effectiveness, safety, and cost of dexmedetomidine for the treatment of agitated delirium refractory to haloperidol in nonintubated critically ill patients.
2016 Jul - Derivation of Novel Risk Prediction Scores for Community-Acquired Sepsis and Severe Sepsis
Wang HE, Donnelly JP, Griffin R, Levitan EB, Shapiro NI, Howard G, Safford MM.; Crit Care Med. 2016 Jul;44(7):1285-94.
Objective: We sought to derive and internally validate a Sepsis Risk Score and a Severe Sepsis Risk Score predicting future sepsis and severe sepsis events among community-dwelling adults.
2016 Jun - Return of Voice for Ventilated Tracheostomy Patients in ICU: A Randomized Controlled Trial of Early-Targeted Intervention
Freeman-Sanderson AL, Togher L, Elkins MR, Phipps PR.; Crit Care Med. 2016 Jun;44(6):1075-81.
Objectives: A cuffed tracheostomy tube facilitates prolonged mechanical ventilation and weaning but usually leads to prolonged voicelessness, which can be one of the most negative experiences of hospitalization. No randomized trials have examined the effects of targeted early communication intervention for the restoration of voice in ventilated tracheostomy patients in the ICU.