Date: 27 Nov 2016; Venue: Intercontinental Grand Stanford Hong Kong
2016 Sep - CUHK JCSPHPC 15th Anniversary International Conference on Innoations in the Public Health Sciences
Date: 23-25 Sep 2016; Venue: School of Public Heath Building, PWH
Wan S, Roberts MA, Mount P.; Cochrane Database Syst Rev. 2016 Aug 9;8:CD010741
BACKGROUND: The ideal intravenous fluid for kidney transplantation has not been defined, despite the common use of normal saline during the peri-operative period. The high chloride content of normal saline is associated with an increased risk of hyperchloraemic metabolic acidosis, which may in turn increase the risk of hyperkalaemia and delayed graft function. Balanced electrolyte solutions have a lower chloride content which may decrease this risk and avoid the need for dialysis due to hyperkalaemia in the immediate post-transplant period. Randomised controlled trials (RCTs) addressing this issue have used biochemical outcomes to compare fluids and have been underpowered to address patient-centred outcomes such as delayed graft function.
Shum HP, Yan WW, Chan TM.; Hong Kong Med J. 2016 Aug 19. [Epub ahead of print]
It has been speculated that extracorporeal blood purification therapies might improve the clinical outcome for patients with severe sepsis, with or without acute kidney injury, since the removal of inflammatory mediators and/or bacterial toxins from circulation could modulate the inflammatory responses that result in organ damage. Despite initial enthusiasm based on promising preliminary results, subsequent investigations did not show sustainable survival benefit. We review the principles and development of blood purification techniques for sepsis and septic acute kidney injury.
Brass P, Hellmich M, Ladra A, Ladra J, Wrzosek A.; Cochrane Database Syst Rev. 2016 Jul 20;7:CD008045.
BACKGROUND: Tracheostomy formation is one of the most commonly performed surgical procedures in critically ill intensive care participants requiring long-term mechanical ventilation. Both surgical tracheostomies (STs) and percutaneous tracheostomies (PTs) are used in current surgical practice; but until now, the optimal method of performing tracheostomies in critically ill participants remains unclear.
2016 Jul - Palliative care for terminally ill patients in the intensive care unit: Systematic review and metaanalysis
Martins BD, Oliveira RA, Cataneo AJ.; Palliat Support Care. 2016 Jul 27:1-8. [Epub ahead of print]
OBJECTIVE: The purpose of our systematic review was to determine whether the introduction of palliative care (PC) teams reduces length of stay and/or mortality for terminally ill patients (TIPs) in an intensive care unit (ICU).
Cutuli SL, Artigas A, Fumagalli R, Monti G, Ranieri VM, Ronco C, Antonelli M; EUPHAS 2 Collaborative Group.; Ann Intensive Care. 2016 Dec;6(1):77. Epub 2016 Aug 8.
BACKGROUND: In 2010, the EUPHAS 2 collaborative group created a registry with the purpose of recording data from critically ill patients suffering from severe sepsis and septic shock treated with polymyxin-B hemoperfusion (PMX-HP) for endotoxin removal. The aim of the registry was to verify the application of PMX-HP in the daily clinical practice.
Minokadeh A, Pinsky MR.; Curr Opin Crit Care. 2016 Aug;22(4):393-400.
Purpose of review: The purpose of the review is to identify the recently validated minimally invasive or noninvasive monitoring devices used to both monitor and guide resuscitation in the critically ill patients.
Samama CM.; Curr Opin Crit Care. 2016 Aug;22(4):365-9.
Purpose of review: New data have been made available in the field of haemostasis and thrombosis. Some long-awaited answers to important questions have been published, and some debates have benefited from an updated perspective.
Goren O, Matot I.; Curr Opin Crit Care. 2016 Aug;22(4):370-8.
Purpose of review: In this review, we discuss the latest updates on perioperative acute kidney injury (AKI) and the specific considerations that are relevant to different surgeries and patient populations.
Wischmeyer PE, McDonald D, Knight R.; Curr Opin Crit Care. 2016 Aug;22(4):347-53.
Purpose of review: Loss of ‘health-promoting’ microbes and overgrowth of pathogenic bacteria (dysbiosis) in ICU is believed to contribute to nosocomial infections, sepsis, and organ failure (multiple organ dysfunction syndrome). This review discusses new understanding of ICU dysbiosis, new data for probiotics and fecal transplantation in ICU, and new data characterizing the ICU microbiome.
Manzanares W, Langlois PL, Hardy G.; Curr Opin Crit Care. 2016 Aug;22(4):308-15.
Purpose of review: Purpose of the review is to summarize recent research addressing the role of intravenous lipid emulsions (IVLEs) in the critically ill.
2016 Aug - Protein Requirements in the Critically Ill: A Randomized Controlled Trial Using Parenteral Nutrition
Ferrie S, Allman-Farinelli M, Daley M, Smith K.; JPEN J Parenter Enteral Nutr. 2016 Aug;40(6):795-805.
BACKGROUND: Current recommendations for higher protein/amino acid provision in the critically ill are based on weak evidence. This double-blinded randomized controlled trial aimed to compare standard amino acid intake with the higher level recommended as the minimum for critically ill patients.
Weijs PJ.; Curr Opin Crit Care. 2016 Aug;22(4):299-302.
Purpose of review: Protein delivery in the critically ill still is a highly debated issue. Here, we discuss only the most recent updates in the literature concerning protein nutrition of the critically ill.
Simpson F, Doig GS.; Curr Opin Crit Care. 2016 Aug;22(4):303-7.
Purpose of review: The purpose of this review is to highlight emerging techniques used to determine body composition early in ICU stay, their prediction of poor outcome, and what is required before they can be more widely used.
Faeq Husain-Syed, Arthur S. Slutsky, and Claudio Ronco Am. J. Resp. Crit. Care Med. Aug 15, 2016, vol. 194, no. 4: 402-414
Discoveries have emerged highlighting the complex nature of the interorgan cross-talk between the kidney and the lung. Vascular rigidity, neurohormonal activation, tissue hypoxia, and abnormal immune cell signaling have been identified as common pathways leading to the development and progression of chronic kidney disease. However, our understanding of the causal relationships between lung injury and kidney injury is not precise.
2015 Aug 15 - Necroptosis: A Novel Cell Death Modality and Its Potential Relevance for Critical Care Medicine
Gabriel Moreno-Gonzalez, Peter Vandenabeele, and Dmitri V. Krysko Am. J. Resp. Crit. Care Med. Aug 15, 2016, vol. 4, no. 4: 415-428
Cell death is intertwined with life in development, homeostasis, pathology, and aging. Until recently, apoptosis was the best known form of programmed cell death, whereas necrosis was for a long time considered accidental owing to physicochemical injury.
2016 Aug 15 - Urinary Glycosaminoglycans Predict Outcomes in Septic Shock and Acute Respiratory Distress Syndrome
Eric P. Schmidt, Katherine H. Overdier, Xiaojun Sun, Lei Lin, Xinyue Liu, Yimu Yang, Lee Anne Ammons, Terra D. Hiller, Matt A. Suflita, Yanlei Yu, Yin Chen, Fuming Zhang, Clay Cothren Burlew, Charles L. Edelstein, Ivor S. Douglas, and Robert J. Linhardt Am. J. Resp. Crit. Care Med. Aug 15, 2016, vol. 194, no. 4: 439-449
Rationale: Degradation of the endothelial glycocalyx, a glycosaminoglycan (GAG)-rich layer lining the vascular lumen, is associated with the onset of kidney injury in animal models of critical illness. It is unclear if similar pathogenic degradation occurs in critically ill patients.
Oshima T, Singer P, Pichard C.; Curr Opin Crit Care. 2016 Aug;22(4):292-8.
Purpose of review: The review focuses on the use of parenteral nutrition and enteral nutrition in critically ill patients to optimize the nutrition care throughout the ICU stay. The key message is: you have the choice!
2016 Aug - Are we creating survivors…or victims in critical care? Delivering targeted nutrition to improve outcomes
Wischmeyer PE.; Curr Opin Crit Care. 2016 Aug;22(4):279-84.
Over the last 10 years, we are proud of the fact we have finally begun to reduce in-hospital mortality following severe sepsis in some countries worldwide. Further, mortality from acute lung injury has fallen dramatically, as the control group mortality in a recent large Acute Respiratory Distress Syndrome Research Network (ARDSnet) trial was strikingly only 16%. But the fundamental question that must be asked is ‘are we winning many battles in our ICUs, but ultimately losing the war?’ ..