2014 Jun - The impact of oxygen and carbon dioxide management on outcome after cardiac arrest

Eastwood GM, Young PJ, Bellomo R.; Curr Opin Crit Care. 2014 Jun;20(3):266-72.

Purpose of review:  To describe the impact of oxygen and carbon dioxide management on patient outcomes following cardiac arrest.

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2014 Jun - Extracorporeal cardiopulmonary resuscitation

Fagnoul D, Combes A, De Backer D.; Curr Opin Crit Care. 2014 Jun;20(3):259-65.

Purpose of review:  To discuss the role of extracorporeal membrane oxygenation (ECMO) in patients with cardiac arrest.

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2014 jun - Early neuroprotection after cardiac arrest

Dell'anna AM, Scolletta S, Donadello K, Taccone FS.; Curr Opin Crit Care. 2014 Jun;20(3):250-8.

Purpose of review:  Many efforts have been made in the last decades to improve outcome in patients who are successfully resuscitated from sudden cardiac arrest. Despite some advances, postanoxic encephalopathy remains the most common cause of death among those patients and several investigations have focused on early neuroprotection in this setting.

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2014 Jun - Towards cardiopulmonary resuscitation without vasoactive drugs

Sunde K, Olasveengen TM.; Curr Opin Crit Care. 2014 Jun;20(3):234-41.

Purpose of review:  Whereas there is clear evidence for improved survival with cardiopulmonary resuscitation (CPR) and defibrillation during cardiac arrest management, there is today lacking evidence that any of the recommended and used drugs lead to any long-term benefit for the patients. In this review, we try to discuss our current view on why advanced life support (ALS) today can be performed without the use of drugs, and instead gain all focus on improving the tasks we know improve survival: CPR and defibrillation.

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2014 Apr - Advances in management and prognostication in critically ill cirrhotic patients

Karvellas CJ, Bagshaw SM.; Curr Opin Crit Care. 2014 Apr;20(2):210-7.

PURPOSE OF REVIEW: To provide an update on the recent publications for the management and prognostication of critically ill cirrhotic patients before and after liver transplant.

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2014 Apr - Update in intensive care medicine: acute liver failure. Initial management, supportive treatment and who to transplant.

Willars C.; Curr Opin Crit Care. 2014 Apr;20(2):202-9.

PURPOSE OF REVIEW: Acute liver failure (ALF) is associated with significant mortality. Although specific therapies may be available, the evidence base for these and for many aspects of supportive therapy has been slow to emerge. Liver transplantation continues to be a cornerstone of treatment, and the management of ALF, therefore, remains the domain of the specialist ICU. The purpose of this review is to identify and critically appraise the recent evidence and to inspire those who strive to provide excellent care for a difficult patient cohort.

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2014 Apr - Fever and therapeutic normothermia in severe brain injury: an update

Bohman LE, Levine JM.; Curr Opin Crit Care. 2014 Apr;20(2):182-8.

PURPOSE OF REVIEW: Fever is common in the ICU among patients with severe brain injury. Fever has been consistently shown to exacerbate brain injuries in animal models and has been consistently associated with poor outcome in human studies. However, whether fever control improves outcome and the ideal means of fever control remain unknown. This review will address recent literature on the impact of fever on severe brain injury and on interventions to maintain normothermia.

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2014 Apr - Minimally invasive surgery for intracerebral haemorrhage

Barnes B, Hanley DF, Carhuapoma JR.; Curr Opin Crit Care. 2014 Apr;20(2):148-52.

PURPOSE OF REVIEW: Spontaneous intracerebral haemorrhage (ICH) imposes a significant health and economic burden on society. Despite this, ICH remains the only stroke subtype without a definitive treatment. Without a clearly identified and effective treatment for spontaneous ICH, clinical practice varies greatly from aggressive surgery to supportive care alone. This review will discuss the current modalities of treatments for ICH including preliminary experience and investigative efforts to advance the care of these patients.

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2014 Apr - Intracranial pressure after the BEST TRIP trial: a call for more monitoring

Le Roux P.; Curr Opin Crit Care. 2014 Apr;20(2):141-7

PURPOSE OF REVIEW:  Increased intracranial pressure (ICP) is associated with worse outcome after traumatic brain injury (TBI), but whether its management improves the outcome is unclear. In this review, we will examine the implications of the Benchmark Evidence from South American Trials: Treatment of Intracranial Pressure (BEST TRIP) trial, evidence for an influence of ICP care on outcome, and a need for greater understanding of the pathophysiology than just ICP through multimodal monitoring (MMM) to enhance the outcome.

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2013 Dec - Rotational thromboelastometry-guided trauma resuscitation

Keene DD, Nordmann GR, Woolley T.: Curr Opin Crit Care. 2013 Dec;19(6):605-12.

Purpose of review: Haemorrhage from major trauma is a significant cause of death worldwide. The UK Defence Medical Service (UK-DMS) has had significant experience in managing severely injured and shocked trauma casualties over the last decade. This has led to the integration of rotational thromboelastometry (ROTEM) into damage control resuscitation delivered at Camp Bastion Field Hospital in Afghanistan. This review aims to describe the rationale for its use and how its use has evolved by UK-DMS.

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2013 Dec - Salvage techniques in traumatic cardiac arrest: thoracotomy, extracorporeal life support, and therapeutic hypothermia

Tisherman SA.; Curr Opin Crit Care. 2013 Dec;19(6):594-8.

Purpose of review: Survival from traumatic cardiac arrest is associated with a very high mortality despite aggressive resuscitation including an Emergency Department thoracotomy (EDT). Novel salvage techniques are needed to improve these outcomes.

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2013 Dec - Utility of simultaneous interventional radiology and operative surgery in a dedicated suite for seriously injured patients

D'Amours SK, Rastogi P, Ball CG.; Curr Opin Crit Care. 2013 Dec;19(6):587-93

Purpose of review: In recent years, combined interventional radiology and operative suites have been proposed and are now becoming operational in select trauma centres. Given the infancy of this technology, this review aims to review the rationale, benefits and challenges of hybrid suites in the management of seriously injured patients.

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2013 Dec - The 'procoagulopathy' of trauma: too much, too late?

Holley AD, Reade MC.; Curr Opin Crit Care. 2013 Dec;19(6):578-86.

Purpose of review: Although early acute traumatic coagulopathy has received much recent attention, the procoagulopathy that often follows appears less appreciated. Thromboembolic disease following trauma is common and lethal, but very effective prophylactic strategies are available. These strategies are variably implemented because of the difficulty in quantifying the magnitude of procoagulopathy in individual patients.

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2013 Dec - Measuring renal function in critically ill patients: tools and strategies for assessing glomerular filtration rate

Macedo E, Mehta RL.; Curr Opin Crit Care. 2013 Dec;19(6):560-6.

Purpose of review: Alterations in kidney function are common in critically ill patients and are generally assessed by changes in serum creatinine (sCr) or urine output, which are considered surrogates for glomerular filtration rate (GFR) but do not reflect the overall kidney function. There is a great need for more reliable measurements of glomerular filtration in order to guide diagnosis and therapy for acute kidney injury. In this review, we will focus on recent advances to measure GFR that could help to better evaluate kidney function and improve patient care.

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2013 Dec - Intravenous fluids in sepsis: what to use and what to avoid

Karakala N, Raghunathan K, Shaw AD.; Curr Opin Crit Care. 2013 Dec;19(6):537-43

Purpose of review: Septic shock is one of the most common and life-threatening conditions afflicting critically ill patients. Intravenous volume resuscitation is considered an initial and very important step in management. The most suitable fluid for volume expansion during septic shock remains unclear. In this review, we focus on the benefits and adverse effects of the most commonly used intravenous fluids in critically ill septic patients.

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2013 Dec - Evolving practices in critical care and their influence on acute kidney injury

Wilson JG, Butcher BW, Liu KD.; Curr Opin Crit Care. 2013 Dec;19(6):523-30

Purpose of review: This review highlights the principal advances in critical care over the past year, and discusses the impact of these advances on the diagnosis and management of acute kidney injury (AKI).

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2013 Oct - Approaches to decreasing medication and other care errors in the ICU

Valentin A.; Curr Opin Crit Care. 2013 Oct;19(5):474-9.

Purpose of review: The very complex process of intensive care is accompanied by a not unexpected accumulation of risk for error and adverse events. The present review addresses strategies to decrease care errors in several domains of daily intensive care practice.

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2013 Oct - Using procalcitonin-guided algorithms to improve antimicrobial therapy in ICU patients with respiratory infections and sepsis

Schuetz P, Raad I, Amin DN.; Curr Opin Crit Care. 2013 Oct;19(5):453-60.

Purpose of review: In patients with systemic bacterial infections hospitalized in ICUs, the inflammatory biomarker procalcitonin (PCT) has been shown to aid diagnosis, antibiotic stewardship, and risk stratification. Our aim is to summarize recent evidence about the utility of PCT in the critical care setting and discuss the potential benefits and limitations of PCT when used for clinical decision-making.

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2013 Oct - Continuous control of tracheal cuff pressure for the prevention of ventilator-associated pneumonia in critically ill patients: where is the evidence?

Rouzé A, Nseir S.; Curr Opin Crit Care. 2013 Oct;19(5):440-7.

Purpose of review: Ventilator-associated pneumonia (VAP) is a major cause of death, morbidity and costs in ICUs. Several evidence-based clinical interventions have been increasingly described for its prevention. However, continuous control of tracheal cuff pressure (Pcuff) is rarely mentioned in the latest clinical guidelines. This review focuses on the available data about the management of Pcuff in the ICU, including discontinuous and continuous control, and its impact on the prevention of VAP.

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2013 Oct - Novelties in pharmacological management of cardiopulmonary resuscitation

Bartos JA, Yannopoulos D.; Curr Opin Crit Care. 2013 Oct;19(5):417-23.

Purpose of review: The ultimate goal of cardiopulmonary resuscitation is long-term neurologically intact survival. Despite numerous well-designed studies, the medications currently used in advanced cardiac life support have not demonstrated success in this regard. This review describes the novel therapeutics under investigation to improve functional recovery and survival.

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