2013 Oct - Intra-Aortic Balloon Pump (IABP) in cardiogenic shock

Fuernau G, Thiele H.; Curr Opin Crit Care. 2013 Oct;19(5):404-9.

Purpose of review: Despite developments in treatment of myocardial infarction, mortality rates in cardiogenic shock remain unacceptably high. Intra-aortic balloon pumping (IABP) is to date the most used device for hemodynamic support, but randomized evidence on survival benefit was lacking.

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2012 Oct - Peripartum cardiomyopathy: update 2012

Bachelier-Walenta K, Hilfiker-Kleiner D, Sliwa K.; Curr Opin Crit Care. 2013 Oct;19(5):397-403

Purpose of review: Peripartum cardiomyopathy (PPCM) is a disorder in which initial left ventricular systolic dysfunction and symptoms of heart failure occur between the late stages of pregnancy and the early postpartum period. Incidences vary geographically; it is common in some countries and rare in others. The acute form of PPCM is a clinical syndrome with reduced cardiac output, tissue hypoperfusion, and increase in the pulmonary capillary wedge pressure. Monitoring of the patient with the acute form of PPCM should be initiated as soon as possible. The syndrome carries a high morbidity and mortality and diagnosis is often delayed. This review focuses on new data and aspects in terms of diagnosis, causes of disease, pharmacological therapy, and management of delivery in patients with PPCM.

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2013 Aug - Perioperative fluids: a clear road ahead?

Peng, Zhi-Yong; Kellum, John A.; Current Opinion in Critical Care. 19(4):353-358, August 2013.

Purpose of review: There is significant controversy for perioperative fluid management. This review discusses the evidence from clinical studies, basic research, and systematic reviews to provide a summary of the current best practice in this area.

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2013 Aug - Blood component transfusion in critically ill patients

McIntyre, Lauralyn; Tinmouth, Alan T.; Fergusson, Dean A.; Current Opinion in Critical Care. 19(4):326-333, August 2013.

Purpose of review: This review summarizes the current evidence base for commonly transfused blood components with a particular focus on the nonacutely bleeding patient.

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2013 Aug - Reducing perioperative cardiac morbidity and mortality: is this the right goal?

Gordon, Emily K.; Fleisher, Lee A.; Current Opinion in Critical Care. 19(4):342-345, August 2013.

Purpose of review: One million people die annually following noncardiac surgery and 4% of patients suffer an adverse cardiac event after surgery. As the number of people having surgery grows, our ability to risk stratify patients becomes more important, particularly in the setting of perioperative myocardial ischemia/necrosis.

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2013 Aug - Fluid administration and the kidney

Prowle, John R.; Bellomo, Rinaldo; Current Opinion in Critical Care. 19(4):308-314, August 2013.

Purpose of review: To review recent studies and information on the relationship between fluid administration and kidney function in critically ill patients.

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2013 Aug - Fluids are drugs: type, dose and toxicity

Raghunathan, Karthik; Shaw, Andrew D.; Bagshaw, Sean M.; Current Opinion in Critical Care. 19(4):290-298, August 2013.

Purpose of review: We discuss the formulation of a prescription for intravenous (i.v.) fluid therapy (a ‘volume prescription’) for critically ill patients: pros/cons of different fluid types; accurate dosing; and qualitative and quantitative toxicities. Updated physiologic concepts are invoked and results of recent major clinical trials on i.v. fluid therapy in the acutely ill are interpreted.

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2013 Aug - The ideal crystalloid - what is 'balanced'?

Morgan, Thomas J.; Current Opinion in Critical Care. 19(4):299-307, August 2013.

Purpose of review: This review explores the contemporary definition of the term ‘balanced crystalloid’ and outlines optimal design features and their underlying rationale.

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2013 Jun - Ventricular diastolic abnormalities in the critically ill

Vignon, Philippe; Current Opinion in Critical Care. 19(3):242-249, June 2013.

Purpose of review: Left-ventricular diastolic dysfunction is associated with various conditions frequently encountered in ICU patients. Due to prolonged relaxation and increased left-ventricular stiffness, patients with diastolic dysfunction are at high risk of developing abrupt pulmonary venous congestion. The present review describes the clinical spectrum of left-ventricular diastolic abnormalities in ICU patients.

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2013 Jun - The role of invasive techniques in cardiopulmonary evaluation

De Backer, Daniel; Fagnoul, David; Herpain, Antoine; Current Opinion in Critical Care. 19(3):228-233, June 2013.

Purpose of review: To discuss the role of the invasive monitoring techniques pulmonary artery catheter (PAC) and transpulmonary thermodilution (TPD) for cardiopulmonary monitoring in the critically ill patient.

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2013 Jun - Extracorporeal life support

Wang, Chih-Hung; Chen, Yih-Sharng; Ma, Matthew Huei-Ming; Current Opinion in Critical Care. 19(3):202-207, June 2013.

Purpose of review: Refractory cardiac arrest still has a grave prognosis under conventional cardiopulmonary resuscitation (CPR). We present the recent studies in extracorporeal CPR (ECPR) for the treatment of refractory cardiac arrest.

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2013 Jun - Airway management in cardiopulmonary resuscitation

Soar, Jasmeet; Nolan, Jerry P.; Current Opinion in Critical Care. 19(3):181-187, June 2013.

Purpose of review: The optimal method for airway management during cardiac arrest is unknown. This review summarizes recent evidence comparing the use of basic and advanced airway interventions [insertion of supraglottic airway (SGA) devices and tracheal intubation], including the role of capnography during cardiac arrest.

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2013 Jun - Management of postcardiac arrest myocardial dysfunction

Bougouin, Wulfran; Cariou, Alain; Current Opinion in Critical Care. 19(3):195-201, June 2013.

Purpose of review: Postresuscitation myocardial dysfunction (PRMD) is a frequent complication, which worsens the hemodynamic status and can be lethal. Early identification and treatment of this cardiac complication is one of the key therapeutic goals during hospitalization of these patients.

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2013 Jun - Is there a role for adrenaline during cardiopulmonary resuscitation?

Nolan, Jerry P.; Perkins, Gavin D.; Current Opinion in Critical Care. 19(3):169-174, June 2013.

Purpose of review: To critically evaluate the recent data on the influence adrenaline has on outcome from cardiopulmonary resuscitation.

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2013 Apr - Haemoglobin management in acute brain injury

LeRoux, Peter; Current Opinion in Critical Care. 19(2):83-91, April 2013

Purpose of review: Anaemia is common among patients in the neurocritical care unit (NCCU) and is thought to exacerbate brain injury. However, the optimal haemoglobin (Hgb) level still remains to be elucidated for traumatic brain injury (TBI), subarachnoid haemorrhage (SAH) and acute ischaemic stroke (AIS). This review outlines recent studies about anaemia and the effects of red blood cell transfusion (RBCT) on outcome in TBI, SAH and AIS patients admitted to the NCCU.

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2013 Apr - New trends in hyperosmolar therapy?

Diringer, Michael N.; Current Opinion in Critical Care. 19(2):77-82, April 2013

Purpose of review: To discuss trends in the use of osmotic therapy.

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2013 Apr - Coagulation pattern in critical liver dysfunction


Schaden, Eva; Saner, Fuat H.; Goerlinger, Klaus; Current Opinion in Critical Care. 19(2):142-148, April 2013.


Purpose of review: This article reviews the current literature dealing with pathophysiology, diagnostics, bleeding management, and thromboprophylaxis in patients with acute and chronic liver dysfunction.

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2013 Apr - Hypoxic liver injury and cholestasis in critically ill patients

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2013 Apr - Extracorporeal liver support


Faybik, Peter; Krenn, Claus-Georg; Current Opinion in Critical Care. 19(2):149-153, April 2013.


Purpose of review: The mortality in patients suffering from liver failure decreased in line with medical progress over the past decades. However, it still remains unacceptably high and liver transplantation still provides the only definite treatment for many patients. The goal of extracorporeal liver support systems is to improve the clinical condition of patients waiting for liver transplantation and/or enhance the regeneration of native injured liver. Nonbiological liver support systems with pure detoxification and biological liver support systems with assumed synthesis and metabolism in addition to detoxification are currently under clinical investigation. Since patient survival is the most significant outcome parameter, we focus in this review on prospective randomized trials with survival rate as primary outcome parameter.

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2013 Apr - Cirrhotic patients in the ICU: prognostic markers and outcome


Saliba, Faouzi; Ichaï, Philippe; Levesque, Eric; Samuel, Didier; Current Opinion in Critical Care. 19(2):154-160, April 2013.


Purpose of review: Give an update on the importance of prognostic scores at admission to the ICU for defining short-term outcome in critically ill cirrhotic patients. Highlight the correlation between the development of sepsis and/or organ failure and outcome.

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