Marin H Kollef. The Lancet, Early Online Publication, 23 January 2010
The Lancet today, Lila Bouadma and colleagues 1 report the results of the PRORATA trial. These investigators assessed the effect of a procalcitonin-guided algorithm on the duration of antimicrobial therapy in critically ill patients. The main findings were that patients in the procalcitonin group had significantly more antibiotic-free days than did those in the control group, who were managed according to present practices. Mortality, relapsing infection, and days free of mechanical ventilation d ...

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