2014 Jan - Critical Care Transition Programs and the Risk of Readmission or Death After Discharge From an ICU: A Systematic Review and Meta-Analysis

Niven DJ, Bastos JF, Stelfox HT.; Crit Care Med. 2014 Jan;42(1):179-87.

Objective: To determine whether critical care transition programs reduce the risk of ICU readmission or death, when compared with standard care among adults who survived their incident ICU admission.

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2013 Nov - Focused Critical Care Echocardiography

Oren-Grinberg A, Talmor D, Brown SM.; Crit Care Med. 2013 Nov;41(11):2618-26.

Objective: Portable ultrasound is now used routinely in many ICUs for various clinical applications. Echocardiography performed by noncardiologists, both transesophageal and transthoracic, has evolved to broad applications in diagnosis, monitoring, and management of critically ill patients. This review provides a current update on focused critical care echocardiography for the management of critically ill patients.

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2013 Nov - Effects of Sitting Position and Applied Positive End-Expiratory Pressure on Respiratory Mechanics of Critically Ill Obese Patients Receiving Mechanical Ventilation

Lemyze M, Mallat J, Duhamel A, Pepy F, Gasan G, Barrailler S, Vangrunderbeeck N, Tronchon L, Thevenin D.; Crit Care Med. 2013 Nov;41(11):2592-9.

Objective: To evaluate the extent to which sitting position and applied positive end-expiratory pressure improve respiratory mechanics of severely obese patients under mechanical ventilation.

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2013 Nov - Validity of Low-Intensity Continuous Renal Replacement Therapy

Uchino S, Toki N, Takeda K, Ohnuma T, Namba Y, Katayama S, Kawarazaki H, Yasuda H, Izawa J, Uji M, Tokuhira N, Nagata I; Japanese Society for Physicians and Trainees in Intensive Care (JSEPTIC) Clinical Trial Group.; Crit Care Med. 2013 Nov;41(11):2584-91.

Objective: To study the hospital mortality of patients with severe acute kidney injury treated with low-intensity continuous renal replacement therapy.

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2013 Nov - A Randomized Controlled Trial of Preoperative Intra-Aortic Balloon Pump in Coronary Patients With Poor Left Ventricular Function Undergoing Coronary Artery Bypass Surgery

Ranucci M, Castelvecchio S, Biondi A, de Vincentiis C, Ballotta A, Varrica A, Frigiola A, Menicanti L; Surgical and Clinical Outcome Research (SCORE) Group.; Crit Care Med. 2013 Nov;41(11):2476-83.

Objective: Preoperative intra-aortic balloon pump use in high-risk patients undergoing surgical coronary revascularization is still a matter of debate. The objective of this study is to determine whether the preoperative use of an intra-aortic balloon pump improves the outcome after coronary operations in high-risk patients.

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2013 Oct - Electrical muscle stimulation in the intensive care setting: a systematic review

Parry SM, Berney S, Granger CL, Koopman R, El-Ansary D, Denehy L.; Crit Care Med. 2013 Oct;41(10):2406-18.

Context: The role of electrical muscle stimulation in intensive care has not previously been systematically reviewed.

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2013 Oct - ICU-Acquired Swallowing Disorders

Macht M, Wimbish T, Bodine C, Moss M.; Crit Care Med. 2013 Oct;41(10):2396-405.

Objectives: Patients hospitalized in the ICU can frequently develop swallowing disorders, resulting in an inability to effectively transfer food, liquids, and pills from their mouth to stomach. The complications of these disorders can be devastating, including aspiration, reintubation, pneumonia, and a prolonged hospital length of stay. As a result, critical care practitioners should understand the optimal diagnostic strategies, proposed mechanisms, and downstream complications of these ICU-acquired swallowing disorders.

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2013 Oct - Procalcitonin versus C-reactive protein for guiding antibiotic therapy in sepsis: a randomized trial

Oliveira CF, Botoni FA, Oliveira CR, Silva CB, Pereira HA, Serufo JC, Nobre V.; Crit Care Med. 2013 Oct;41(10):2336-43.

Objective: We sought to evaluate whether procalcitonin was superior to C-reactive protein in guiding antibiotic therapy in intensive care patients with sepsis.

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2013 Oct - RBC Transfusion Practices Among Critically Ill Patients: Has Evidence Changed Practice?

Murphy DJ, Needham DM, Netzer G, Zeger SL, Colantuoni E, Ness P, Pronovost PJ, Berenholtz SM.; Crit Care Med. 2013 Oct;41(10):2344-2353.

Objective: Increasing evidence, including publication of the Transfusion Requirements in Critical Care trial in 1999, supports a lower hemoglobin threshold for RBC transfusion in ICU patients. However, little is known regarding the influence of this evidence on clinical practice over time in a large population-based cohort.

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2013 Oct - Restrictive Versus Liberal Transfusion Strategies for Older Mechanically Ventilated Critically Ill Patients: A Randomized Pilot Trial

Walsh TS, Boyd JA, Watson D, Hope D, Lewis S, Krishan A, Forbes JF, Ramsay P, Pearse R, Wallis C, Cairns C, Cole S, Wyncoll D; for the RELIEVE Investigators.; Crit Care Med. 2013 Oct;41(10):2354-2363.

Objectives: To compare hemoglobin concentration (Hb), RBC use, and patient outcomes when restrictive or liberal blood transfusion strategies are used to treat anemic (Hb ≤ 90 g/L) critically ill patients of age ≥ 55 years requiring ≥ 4 days of mechanical ventilation in ICU.

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2013 Oct - The Impact of Rapid Response Team on Outcome of Patients Transferred From the Ward to the ICU: A Single-Center Study

Karpman C, Keegan MT, Jensen JB, Bauer PR, Brown DR, Afessa B.; Crit Care Med. 2013 Oct;41(10):2284-91.

Objectives: To determine the impact of rapid response team implementation on the outcome of patients transferred from the regular hospital ward and nonward locations to the ICU.

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2013 Oct - Do Intensivist Staffing Patterns Influence Hospital Mortality Following ICU Admission? A Systematic Review and Meta-Analyses

Wilcox ME, Chong CA, Niven DJ, Rubenfeld GD, Rowan KM, Wunsch H, Fan E.; Crit Care Med. 2013 Oct;41(10):2253-2274.

Objective: To determine the effect of different intensivist staffing models on clinical outcomes for critically ill patients.

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2013 Sep - Blood purification and mortality in sepsis: a meta-analysis of randomized trials

Zhou F, Peng Z, Murugan R, Kellum JA.; Crit Care Med. 2013 Sep;41(9):2209-20.

Objectives: Although blood purification improves outcomes in animal studies of sepsis, results of clinical trials have been mixed. We conducted a systematic review and meta-analysis of randomized trials to determine the association between various blood purification techniques and all-cause mortality in humans with sepsis.

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2013 Sep - Central or Peripheral Catheters for Initial Venous Access of ICU Patients: A Randomized Controlled Trial

Ricard, Jean-Damien; Salomon, Laurence; Boyer, Alexandre; Thiery, Guillaume; Meybeck, Agnes; Roy, Carine; Pasquet, Blandine; Le Mière, Eric; Dreyfuss, Didier; Crit Care Med. 2013 Sep;41(9):2108-2115.

Objectives: The vast majority of ICU patients require some form of venous access. There are no evidenced-based guidelines concerning the use of either central or peripheral venous catheters, despite very different complications. It remains unknown which to insert in ICU patients. We investigated the rate of catheter-related insertion or maintenance complications in two strategies: one favoring the central venous catheters and the other peripheral venous catheters.

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2013 Sep - Microvascular Effects of Heart Rate Control With Esmolol in Patients With Septic Shock: A Pilot Study

Morelli A, Donati A, Ertmer C, Rehberg S, Kampmeier T, Orecchioni A, D'Egidio A, Cecchini V, Landoni G, Pietropaoli P, Westphal M, Venditti M, Mebazaa A, Singer M.; Crit Care Med. 2013 Sep;41(9):2162-2168.

Objective: β-blocker therapy may control heart rate and attenuate the deleterious effects of β-stimulating catecholamines in septic shock. However, their negative chronotropy and inotropy may potentially lead to an inappropriately low cardiac output, with a subsequent compromise of microvascular blood flow. The purpose of the present pilot study was to investigate the effects of reducing heart rate to less than 95 beats per minute in patients with septic shock using the β-1 adrenoceptor blocker, esmolol, with specific focus on systemic hemodynamics and the microcirculation.

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2013 Sep - Impact of regular collaboration between infectious diseases and critical care practitioners on antimicrobial utilization and patient outcome

Rimawi RH, Mazer MA, Siraj DS, Gooch M, Cook PP.; Crit Care Med. 2013 Sep;41(9):2099-107.

Objective: Antimicrobial stewardship programs have been shown to help reduce the use of unnecessary antimicrobial agents in the hospital setting. To date, there has been very little data focusing on high-use areas, such as the medical ICU. A prospective intervention was done to assess guideline compliance, antimicrobial expenditure, and healthcare cost when an infectious disease fellow interacts regularly with the medical ICU team.

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2013 Sep - Implementing Delirium Screening in the ICU: Secrets to Success

Brummel NE, Vasilevskis EE, Han JH, Boehm L, Pun BT, Ely EW.; Crit Care Med. 2013 Sep;41(9):2196-2208.

Objective: To review delirium screening tools available for use in the adult ICU and PICU, to review evidence-based delirium screening implementation, and to discuss common pitfalls encountered during delirium screening in the ICU.

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2013 Sep - The Systemic Inflammatory Response Syndrome in Patients With ST-Segment Elevation Myocardial Infarction

van Diepen S, Vavalle JP, Newby LK, Clare R, Pieper KS, Ezekowitz JA, Hochman JS, Mahaffey KW, Armstrong PW, Granger CB.; Crit Care Med. 2013 Sep;41(9):2080-7.

OBJECTIVES: To assess whether systemic inflammatory response syndrome is associated with morbidity and mortality in ST-elevation myocardial infarction.

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2013 Sep - A Randomized, Double-Blind, Placebo-Controlled, Phase 2b Study to Evaluate the Safety and Efficacy of Recombinant Human Soluble Thrombomodulin, ART-123, in Patients With Sepsis and Suspected Disseminated Intravascular Coagulation

Vincent JL, Ramesh MK, Ernest D, Larosa SP, Pachl J, Aikawa N, Hoste E, Levy H, Hirman J, Levi M, Daga M, Kutsogiannis DJ, Crowther M, Bernard GR, Devriendt J, Puigserver JV, Blanzaco DU, Esmon CT, Parrillo JE, Guzzi L, Henderson SJ, Pothirat C, Mehta P, Fareed J, Talwar D, Tsuruta K, Gorelick KJ, Osawa Y, Kaul I.; Crit Care Med. 2013 Sep;41(9):2069-2079.

OBJECTIVES: To determine the safety and efficacy of recombinant thrombomodulin (ART-123) in patients with suspected sepsis-associated disseminated intravascular coagulation.

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2013 Sep - Heparin Thromboprophylaxis in Medical-Surgical Critically Ill Patients: A Systematic Review and Meta-Analysis of Randomized Trials

Alhazzani W, Lim W, Jaeschke RZ, Murad MH, Cade J, Cook DJ.; Crit Care Med. 2013 Sep;41(9):2088-98.

Objective: Venous thromboembolism prevention during critical illness is a widely used quality metric. The objective of this systematic review was to systematically review the efficacy and safety of heparin thromboprophylaxis in medical-surgical patients in the ICU.

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