2013 Jun - Assessment and clinical course of hypocalcemia in critical illness

Tom Steele, Ruwanthi Kolamunnage-Dona, Colin Downey, Cheng-Hock Toh, Ingeborg Welters; Critical Care 2013, 17:R106 (4 June 2013)

Introduction: Hypocalcemia is common in critically ill patients. However, its clinical course during the early days of admission and the role of calcium supplementation remain uncertain, and the assessment of calcium status is inconsistent. We aimed to establish the course of hypocalcemia during the early days of critical illness in relation to mortality and to assess the impact of calcium supplementation on calcium normalization and mortality.

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2013 Jun - Antipyretic therapy in febrile critically ill adults: A systematic review and meta-analysis

Niven DJ, Stelfox HT, Laupland KB.; J Crit Care. 2013 Jun;28(3):303-10.

PURPOSE: To determine whether fever control with antipyretic therapy effects the mortality of febrile critically ill adults.

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2013 Jun - Perioperative plasma melatonin concentration in postoperative critically ill patients: Its association with delirium

Yoshitaka S, Egi M, Morimatsu H, Kanazawa T, Toda Y, Morita K.; J Crit Care. 2013 Jun;28(3):236-42.

PURPOSE: Delirium is a common complication in postoperative critically ill patients. Although abnormal melatonin metabolism is thought to be one of the mechanisms of delirium, there have been few studies in which the association between alteration of perioperative plasma melatonin concentration and postoperative delirium was assessed.

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2013 May - Interactions between the volume effects of hydroxyethyl starch 130/0.4 and Ringer's acetate

Robert G Hahn, Christian Bergek, Tobias Geback, Joachim Zdolsek Critical Care 2013, 17:R104 (29 May 2013)

Introduction: The turnover of Ringer's solutions is greatly dependent on the physiological situation, such as the presence of dehydration or anaesthesia. The present study evaluates whether the kinetics is affected by previous infusion of colloid fluid.

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2013 May - A systematic review of tools for predicting severe adverse events following patient discharge from intensive care units

F Shaun Hosein, Niklas Bobrovitz, Simon Berthelot, David A Zygun, William A Ghali, Henry T Stelfox Critical Care 2013, 17:R102 (29 May 2013)

Introduction: The discharge of patients from the intensive care unit (ICU) to a hospital ward is a common transition of care that is associated with error and adverse events. Risk stratification tools may help identify high-risk patients for targeted interventions, but it is unclear if proper tools have been developed.

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2013 May - Statins and trauma - a systematic review

Jan O Jansen, Janet M Lord, David R Thickett, Mark J Midwinter, Daniel F McAuley, Fang Gao Critical Care 2013, 17:227 (29 May 2013)

Statins, in addition to their lipid-lowering properties, have anti-inflammatory actions. The aim of this review was to evaluate the effect of pre-injury statin use, and statin treatment, following injury.


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2013 May - Continuous on-line glucose measurement by microdialysis in a central vein. A pilot study

Christina Blixt, Olav Rooyackers, Bengt Isaksson, Jan Wernerman Critical Care 2013, 17:R87 (11 May 2013)

Introduction: Tight glucose control in the ICU has been proven difficult with an increased risk for hypoglycaemic episodes. Also the variability of glucose may have an impact on morbidity. An accurate and feasible on-line/continuous measurement is therefore desired. In this study a central vein catheter with a microdialysis membrane in combination with an on-line analyzer for continuous monitoring of circulating glucose and lactate by the central route was tested.

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2013 Mar - Recombinant factor VIIa for uncontrollable bleeding in patients with extracorporeal membrane oxygenation: report on 15 cases and literature review

Repressé X, Au SM, Brechot N, Trouillet J, Leprince P, Chastre J, Combes A, Luyt CE; Crit Care 2013, 17:R55.

INTRODUCTION: Bleeding is the most frequent complication in patients on venoarterial or venovenous extracorporeal membrane oxygenation (ECMO). Recombinant activated factor VII (rFVIIa) has been used in these patients with conflicting results. We describe our experience using rFVIIa for refractory bleeding in this setting and review the cases reported in the literature.

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2013 Mar - New biomarker panel of plasma neutrophil gelatinase-associated lipocalin and endotoxin activity assay for detecting sepsis in acute kidney injury

Katagiri D, Doi K, Matsubara T, Negishi K, Hamasaki Y, Nakamura K, Ishii T, Yahagi N, Noiri E.; J Crit Care. 2013 Mar 14. [Epub ahead of print]

PURPOSE: Septic acute kidney injury (AKI) shows an unacceptably high mortality rate. Detection of sepsis is important for the clinical management of AKI patients. This study was undertaken to evaluate 2 biomarkers of neutrophil gelatinase-associated lipocalin (NGAL) and endotoxin activity (EA) assay and their combination for detecting sepsis in AKI.

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2013 Apr - Clinical review: Brain-body temperature differences in adults with severe traumatic brain injury

Childs C, Lunn KW.; Crit Care. 2013 Apr 22;17(2):222. [Epub ahead of print]

Surrogate or 'proxy' measures of brain temperature are used in the routine management of patients with brain damage. The prevailing view is that the brain is 'hotter' than the body. The polarity and magnitude of temperature differences between brain and body, however, remains unclear after severe traumatic brain injury (TBI). The focus of this systematic review is on the adult patient admitted to intensive/neurocritical care with a diagnosis of severe TBI (Glasgow Coma Scale score of less than 8)...

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2013 Apr - Changing trends in the use of seizure prophylaxis after traumatic brain injury: A shift from phenytoin to levetiracetam

Kruer RM, Harris LH, Goodwin H, Kornbluth J, Thomas KP, Slater LA, Haut ER.; J Crit Care. 2013 Apr 5.  [Epub ahead of print]

PURPOSE: Current guidelines for traumatic brain injury (TBI) recommend antiepileptic drugs (AEDs) for 7 days after injury to decrease posttraumatic seizure risk. Phenytoin decreases seizure risk 73% vs placebo during this time. Levetiracetam (LEV) is an alternative; however, no published data validate comparable efficacy. Our objective was to evaluate seizure incidence 7 days after TBI in patients treated with phenytoin (PHT) vs LEV and to characterize practice of AED selection.

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2013 Apr - Accuracy of the chest radiograph to identify bilateral pulmonary infiltrates consistent with the diagnosis of acute respiratory distress syndrome using computed tomography as reference standard

Figueroa-Casas JB, Brunner N, Dwivedi AK, Ayyappan AP.; J Crit Care. 2013 Apr 5.  [Epub ahead of print]

PURPOSE: The purpose of the study is to evaluate the diagnostic accuracy of the anteroposterior chest radiograph to detect pulmonary abnormalities consistent with acute respiratory distress syndrome (ARDS).

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2013 Apr - Tracheostomy teams reduce total tracheostomy time and increase speaking valve use: a systematic review and meta-analysis

Speed L, Harding KE.; J Crit Care. 2013 Apr;28(2):216.e1-10.

PURPOSE: Multidisciplinary tracheostomy teams have been implemented in acute hospitals over the past 10 years. This systematic review of the literature and meta-analysis aimed to assess the effect of tracheostomy teams on patient outcomes.

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2013 Mar - A touch of cooling may help

Zaaqoq AM, Yende S.; Crit Care. 2013 Mar 6;17(2):306. [Epub ahead of print]
BACKGROUND: Fever control may improve vascular tone and decrease oxygen consumption; however, fever may help combat infection.

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2013 Apr - Effect of enteral feeding with ginger extract in acute respiratory distress syndrome

Vahdat Shariatpanahi Z, Mokhtari M, Taleban FA, Alavi F, Salehi Surmaghi MH, Mehrabi Y, Shahbazi S.; J Crit Care. 2013 Apr;28(2):217.e1-6
PURPOSE: The purpose of this study is to evaluate the effects of an enteral diet enriched with ginger extract on inflammatory factors, respiratory profile, and outcome of patients with acute respiratory distress syndrome (ARDS).

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2013 Apr - Prophylactic magnesium for improving neurologic outcome after aneurysmal subarachnoid hemorrhage: Systematic review and meta-analysis


Golan E, Vasquez DN, Ferguson ND, Adhikari NK, Scales DC.; J Crit Care. 2013 Apr;28(2):173-81.
PURPOSE: Neurologic disability is common after aneurysmal subarachnoid hemorrhage (aSAH). Our objective was to systematically review the prophylactic use of magnesium to improve neurologic outcomes in these patients.

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2013 Apr - Effects of intravenous low-dose recombinant human atrial natriuretic peptide on renal function in the perioperative management for gastrointestinal perforation or ileus: A retrospective single-center study

Maruta T, Otao G, Miyazato T, Maruta N, Yamauchi K, Yano T, Kawano T, Tsuneyoshi I.; J Crit Care. 2013 Apr;28(2):133-40.
PURPOSE: We studied the effectiveness of human atrial natriuretic peptide (hANP) on management of acute kidney injury.

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2013 Apr - A critical appraisal of the accuracy of the RIFLE and AKIN classifications in defining "acute kidney insufficiency" in critically ill patients

Valette X, du Cheyron D.; J Crit Care. 2013 Apr;28(2):116-25.
Purpose: The lack of a consensus definition for acute kidney injury (AKI) has led to a great deal of discrepancies and confusion in the literature in this field. Thus, the RIFLE (Risk of renal dysfunction, Injury to the kidney, Failure of kidney function, Loss of kidney function and End-stage renal disease) and Acute Kidney Injury Network (AKIN) classifications were developed by multidisciplinary collaborative groups and were validated by experts in an international consensus conference in 2007 under an umbrella “acute kidney insufficiency” definition.

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2013 Feb - Role of new biomarkers: functional and structural damage

Tsigou E, Psallida V, Demponeras C, Boutzouka E, Baltopoulos G.; Crit Care Res Pract. 2013;2013:361078.
Traditional diagnosis of acute kidney injury (AKI) depends on detection of oliguria and rise of serum creatinine level, which is an unreliable and delayed marker of kidney damage. Delayed diagnosis of AKI in the critically ill patient is related to increased morbidity and mortality, prolonged length of stay, and cost escalation. The discovery of a reliable biomarker for early diagnosis of AKI would be very helpful in facilitating early intervention, evaluating the effectiveness of therapy, and eventually reducing cost and improving outcome...

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2013 Feb - Volume management in the critically ill patient with acute kidney injury

Labib M, Khalid R, Khan A, Khan S.; Crit Care Res Pract. 2013;2013:792830.
Acute kidney injury (AKI) frequently occurs in the setting of critical illness and its management poses a challenge for the intensivist. Optimal management of volume status is critical in the setting of AKI in the ICU patient...

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