2011 Jul - Ultrasonography of optic nerve sheath diameter for detection of raised intracranial pressure: a systematic review and meta-analysis [Review]
Dubourg J, Javouhey E, Geeraerts T, Messerer M, Kassai B.; Intensive Care Med. 2011 Jul;37(7):1059-68. Epub 2011 Apr 20.
PURPOSE: To evaluate the diagnostic accuracy of ultrasonography of optic nerve sheath diameter (ONSD) for assessment of intracranial hypertension.
2011 Jun - Severity assessment tools to guide ICU admission in community-acquired pneumonia: systematic review and meta-analysis [Review]
Chalmers JD, Mandal P, Singanayagam A, Akram AR, Choudhury G, Short PM, Hill AT.Intensive Care Med. 2011 Jun 10. [Epub ahead of print]
BACKGROUND: The aim of this meta-analysis was to determine if severity assessment tools can be used to guide decisions regarding intensive care unit (ICU) admission of patients with community-acquired pneumonia.
2011 Jun - Improved survival in severe paraquat poisoning with repeated pulse therapy of cyclophosphamide and steroids
Lin JL, Lin-Tan DT, Chen KH, Huang WH, Hsu CW, Hsu HH, Yen TH.; Intensive Care Med. 2011 Jun;37(6):1006-13. Epub 2011 Feb 15.
PURPOSE: To clarify the efficacy of repeated methylprednisolone (MP) and cyclophosphamide (CP) pulse therapy and daily dexamethasone (DEX) therapy in patients with severe paraquat (PQ) poisoning
2011 Jun - Long-term sedation in intensive care unit: a randomized comparison between inhaled sevoflurane and intravenous propofol or midazolam
Mesnil M, Capdevila X, Bringuier S, Trine PO, Falquet Y, Charbit J, Roustan JP, Chanques G, Jaber S. ; Intensive Care Med. 2011 Jun;37(6):933-41. Epub 2011 Mar 29.
Purpose: To evaluate efficacy and adverse events related to inhaled sevoflurane for long-term sedation compared with standard intravenous (IV) sedation with propofol or midazolam.
2011 Jun - Acute intestinal failure in critically ill patients: is plasma citrulline the right marker? [Review]
Piton G, Manzon C, Cypriani B, Carbonnel F, Capellier G.; Intensive Care Med. 2011 Jun;37(6):911-7. Epub 2011 Mar 12.
INTRODUCTION: Small bowel functions are more complex than colon functions, and short bowel conditions are associated with increased mortality. Gastrointestinal dysfunction in critically ill patients is common, probably underestimated, and associated with a poor prognosis. However, a validated definition of acute intestinal failure is lacking, in absence of a marker to measure it. Consequently, small bowel dysfunction is not clearly integrated into the overall approach used to treat ICU patients.
Chiumello D, Chevallard G, Gregoretti C.;Intensive Care Med. 2011 Mar 18. [Epub ahead of print]
BACKGROUND:Postoperative pulmonary complications, generally defined as any pulmonary abnormality occurring in the postoperative period, are still a significant issue in clinical practice increasing hospital length of stay, morbidity and mortality. Non-invasive ventilation (NIV), primarily applied in cardiogenic pulmonary edema, decompensated COPD and hypoxemic pulmonary failure, is nowadays also used in perioperative settings.
2011 May - Retrieval of critically ill adults using extracorporeal membrane oxygenation: an Australian experience
Forrest P, Ratchford J, Burns B, Herkes R, Jackson A, Plunkett B, Torzillo P, Nair P, Granger E, Wilson M, Pye R.Intensive Care Med. 2011 May;37(5):824-30. Epub 2011 Feb 26.
PURPOSE: A retrieval program was developed in New South Wales (NSW), Australia to provide extracorporeal membrane oxygenation support (ECMO) for the safe transport of adults with severe, acute respiratory or cardiac failure. We describe the development and results of this program and the impact of the 2009 H1N1 epidemic on this service.
Valenta J, Brodska H, Drabek T, Hendl J, Kazda A.; Intensive Care Med. 2011 May;37(5):808-15. Epub 2011 Feb 24.
OBJECTIVE: Systemic inflammatory response syndrome (SIRS) and sepsis remain the leading cause of death in the critically ill. A reduction in the antioxidant capacity, including selenoenzymes that are dependent on selenium (Se), could be a contributing factor. Se supplementation in septic patients have yielded conflicting results. We hypothesized that a high-dose Se supplementation would (1) improve markers of inflammation, nutrition and antioxidant defence, and (2) decrease mortality.
Pettilä V, Webb SA, Bailey M, Howe B, Seppelt IM, Bellomo R.; Intensive Care Med. 2011 May;37(5):763-7. Epub 2011 Mar 11.
OBJECTIVE: We aim to evaluate the incidence and outcome of acute kidney injury (AKI) among critically ill adult patients with H1N1 2009 infection.
Weng L, Joynt GM, Lee A, Du B, Leung P, Peng J, Gomersall CD, Hu X, Yap HY; The Chinese Critical Care Ethics Group.; Intensive Care Med. 2011 Apr;37(4):655-664. Epub 2011 Jan 25.
INTRODUCTION: Critical care doctors are frequently faced with clinical problems that have important ethical and moral dimensions. While Western attitudes and practice are well documented, little is known of the attitudes or practice of Chinese critical care doctors.
2011 Apr - The tight calorie control study (TICACOS): a prospective, randomized, controlled pilot study of nutritional support in critically ill patients
Singer P, Anbar R, Cohen J, Shapiro H, Shalita-Chesner M, Lev S, Grozovski E, Theilla M, Frishman S, Madar Z.; Intensive Care Med. 2011 Apr;37(4):601-9. Epub 2011 Feb 22.
PURPOSE: To determine whether nutritional support guided by repeated measurements of resting energy requirements improves the outcome of critically ill patients.
2011 Mar - The effect of etomidate on adrenal function in critical illness: a systematic review [Review]
Albert SG, Ariyan S, Rather A.; Intensive Care Med. 2011 Mar 4. [Epub ahead of print]
PURPOSE: Although etomidate is a preferred anesthetic agent for rapid sequence intubation (RSI) in critical illness, as an inhibitor of cortisol synthesis (11β-hydroxylase), it may be associated with adrenal dysfunction. The objectives are to review the effects of etomidate versus comparator anesthetics in critical illness for: primary outcome of mortality and secondary outcome of adrenal insufficiency (AI).
2011 Mar - Serum and urine cystatin C are poor biomarkers for acute kidney injury and renal replacement therapy
Royakkers AA, Korevaar JC, van Suijlen JD, Hofstra LS, Kuiper MA, Spronk PE, Schultz MJ, Bouman CS.; Intensive Care Med. 2011 Mar;37(3):493-501.
PURPOSE: To evaluate whether cystatin C in serum (sCyC) and urine (uCyC) can predict early acute kidney injury (AKI) in a mixed heterogeneous intensive care unit (ICU), and also whether these biomarkers can predict the need for renal replacement therapy (RRT).
2011 Mar - Low-dose steroids for septic shock and severe sepsis: the use of Bayesian statistics to resolve clinical trial controversies
Kalil AC, Sun J.; Intensive Care Med. 2011 Mar;37(3):420-9.
PURPOSE: Low-dose steroids have shown contradictory results in trials and three recent meta-analyses. We aimed to assess the efficacy and safety of low-dose steroids for severe sepsis and septic shock by Bayesian methodology.
2011 Feb - Use of early corticosteroid therapy on ICU admission in patients affected by severe pandemic (H1N1)v influenza A infection
Martin-Loeches I, Lisboa T, Rhodes A, Moreno RP, Silva E, Sprung C, Chiche JD, Barahona D, Villabon M, ; Balasini C, Pearse RM, Matos R, Rello J; The ESICM H1N1 Registry Contributors.Intensive Care Med. 2011 Feb;37(2):272-283.
INTRODUCTION: Early use of corticosteroids in patients affected by pandemic (H1N1)v influenza A infection, although relatively common, remains controversial.
Piquilloud L, Vignaux L, Bialais E, Roeseler J, Sottiaux T, Laterre PF, Jolliet P, Tassaux D.; Intensive Care Med. 2011 Feb;37(2):263-71PURPOSE: To determine if, compared with pressure support (PS), neurally adjusted ventilatory assist (NAVA) reduces trigger delay, inspiratory time in excess, and the number of patient-ventilator asynchronies in intubated patients.
Volpicelli G.; Intensive Care Med. 2011 Feb;37(2):224-32.
PURPOSE: Over the last decade, the use of ultrasound as a technique to look for pneumothorax has rapidly evolved. This review aims to analyze and synthesize current knowledge on lung ultrasound targeted at the diagnosis of pneumothorax. The technique and its usefulness in different scenarios are explained, and its merits over conventional radiology are highlighted.
2011 Jan - Probiotics versus antibiotic decontamination of the digestive tract: infection and mortality
Oudhuis GJ, Bergmans DC, Dormans T, Zwaveling JH, Kessels A, Prins MH, Stobberingh EE, Verbon A.; Intensive Care Med. 2011 Jan;37(1):110-7.
PURPOSE: Selective decontamination of the digestive tract (SDD) has been shown to decrease the infection rate and mortality in intensive care units (ICUs); Lactobacillus plantarum 299/299v plus fibre (LAB) has been used for infection prevention and does not harbour the potential disadvantages of antibiotics. The objective was to assess whether LAB is not inferior to SDD in infection prevention.
Thibault R, Pichard C, Wernerman J, Bendjelid K.; Intensive Care Med. 2011 Jan;37(1):35-45.
Cardiogenic shock is a common diagnosis in patients in the intensive care unit (ICU), and is characterized by a decreased cardiac output in the presence of adequate intravascular volume associated with an inadequate tissue perfusion including a physiological reduction in the splanchnic territory. It may occur in isolation as a reflection of cardiac pathology, or it may be part of a shock syndrome involving other pathogenic mechanisms. As the use of enteral nutrition (EN) is associated with an increase in mesenteric arterial output, EN could be deleterious by overwhelming the mechanisms of mesenteric adaptation. Accordingly, EN has been suspected to increase the risk of mesenteric ischaemia, bacterial translocation and sepsis in ICU patients with cardiogenic shock.
2010 Dec - Clinical effects of adding fludrocortisone to a hydrocortisone-based shock protocol in hypotensive critically ill children
Hebbar KB, Stockwell JA, Fortenberry JD.; Intensive Care Med. 2010 Dec 9. [Epub ahead of print]
BACKGROUND: Adult studies evaluating corticosteroids have found varied efficacy. One study showing mortality benefit utilized fludrocortisone (FLU) and hydrocortisone (HC) (Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA 288:862-871, 2002). Use of FLU in children has not been described. We developed a protocol using HC for systemic inflammatory response syndrome (SIRS) and shock with optional addition of FLU.