2010 Nov - Extrapolation from ten sections can make CT-based quantification of lung aeration more practicable
Reske AW, Reske AP, Gast HA, Seiwerts M, Beda A, Gottschaldt U, Josten C, Schreiter D, Heller N, Wrigge H, Amato MB.; Intensive Care Med. 2010 Nov;36(11):1836-44.
PURPOSE: Clinical applications of quantitative computed tomography (qCT) in patients with pulmonary opacifications are hindered by the radiation exposure and by the arduous manual image processing. We hypothesized that extrapolation from only ten thoracic CT sections will provide reliable information on the aeration of the entire lung.
2010 Aug - Monitoring the microcirculation in the critically ill patient: current methods and future approaches
PURPOSE: To discuss the techniques currently available to evaluate the microcirculation in critically ill patients. In addition, the most clinically relevant microcirculatory alterations will be discussed.
2010 Sep - Probiotics in the critically ill patient: a double blind, randomized, placebo-controlled trial
2010 Aug - Gastric residual volume during enteral nutrition in ICU patients: the REGANE study
OBJECTIVE: To compare the effects of increasing the limit for gastric residual volume (GRV) in the adequacy of enteral nutrition. Frequency of gastrointestinal complications and outcome variables were secondary goals.
2010 Aug - The impact of fluid therapy on microcirculation and tissue oxygenation in hypovolemic patients: a review
Purpose:An optimal volume replacement strategy aims to restore systemic hemodynamics with the ultimate goals of improving organ perfusion and microcirculation for sustaining adequate tissue oxygenation. This review presents the (patho)physiological basis of hypovolemia, microcirculation, and tissue oxygenation and presents a literature review on the effects of plasma substitutes on microperfusion and oxygenation in the clinical setting.
2010 Jul - Impact of body mass on incidence and prognosis of acute kidney injury requiring renal replacement therapy
Druml W, Metnitz B, Schaden E, Bauer P, Metnitz PG.; Intensive Care Med. 2010 Jul;36(7):1221-8.
PURPOSE: In patients with chronic kidney disease, survival has been shown to be better with increasing body mass, an observation which was termed the "obesity paradox". To investigate if such an effect would also be present in patients with acute kidney injury (AKI), we analysed the impact of body mass on the prognosis of intensive care patients with severe AKI requiring renal replacement therapy.
2010 Jul - Effectiveness of simple daily sensitization of physicians to the duration of central venous and urinary tract catheterization
Seguin P, Laviolle B, Isslame S, Coué A, Mallédant Y.; Intensive Care Med. 2010 Jul;36(7):1202-6. Epub 2010 Mar 18.
PURPOSE: To evaluate the effectiveness of simple daily sensitization of physicians to the duration of central venous and urinary tract catheterization, and impact on infection rates.
2010 Jul - Transfusion practice and guidelines in Australian and New Zealand intensive care units.
The Blood Observational Study Investigators on behalf of the ANZICS-Clinical Trials Group.; Intensive Care Med. 2010 Jul;36(7):1138-1146. Epub 2010 May 4.
OBJECTIVE: To describe the relationship between clinical practice and national guidelines for the transfusion of red blood cells (RBCs), fresh frozen plasma (FFP), platelets, and cryoprecipitate in Australian and New Zealand intensive care units (ICUs).
2010 Jul - Direct thrombin inhibitors: pharmacology and application in intensive care medicine
Schaden E, Kozek-Langenecker SA.; Intensive Care Med. 2010 Jul;36(7):1127-37. Epub 2010 Apr 28.
Purpose: Anticoagulation is part of the daily routine of intensive care physicians. As the possibilities of pharmacological anticoagulation are becoming more numerous and diverse, intensive care physicians have to be familiar with indications, contraindications, dosing, and reversal of many different substances. This paper presents an overview of the substance group of direct thrombin inhibitors (DTI) indicated for alternative anticoagulation in intensive care medicine.
2010 May - Target-controlled infusion of propofol for sedation in patients with non-invasive ventilation failure due to low tolerance: a preliminary study.
Clouzeau B, Bui HN, Vargas F, Grenouillet-Delacre M, Guilhon E, Gruson D, Hilbert G.; Intensive Care Med. 2010 May 11. PURPOSE: Non-invasive ventilation (NIV) in critically ill patients is associated with a high failure rate. This prospective study assessed the feasibility and safety of target-controlled infusion (TCI) of propofol for conscious sedation during NIV in patients with NIV failure due to low tolerance.
2010 May - Do hypooncotic fluids for shock increase the risk of late-onset acute respiratory distress syndrome?
OBJECTIVE: In patients with shock, late-onset acute respiratory distress syndrome (ARDS) carries poor prognosis. Hypooncotic fluids may improve kidney function preservation, whereas hyperoncotic fluids may in theory decrease the risk of late-onset ARDS. Our objective was to determine whether predominant or exclusive use of crystalloids and/or hypooncotic colloids for shock resuscitation influenced the risk of late-onset ARDS.
2010 Mar - Gastric residual volume during enteral nutrition in ICU patients: the REGANE study.
Montejo JC, Miñambres E, Bordejé L, Mesejo A, Acosta J, Heras A, Ferré M, Fernandez-Ortega F, Vaquerizo CI, Manzanedo R.; Intensive Care Med. 2010 Mar 16.
OBJECTIVE: To compare the effects of increasing the limit for gastric residual volume (GRV) in the adequacy of enteral nutrition. Frequency of gastrointestinal complications and outcome variables were secondary goals.
2010 May - Lipid emulsions in parenteral nutrition of intensive care patients: current thinking and future directions [Review]
Calder PC, Jensen GL, Koletzko BV, Singer P, Wanten GJ.; Intensive Care Med. 2010 May;36(5):735-49.
BACKGROUND: Energy deficit is a common and serious problem in intensive care units and is associated with increased rates of complications, length of stay, and mortality. Parenteral nutrition (PN), either alone or in combination with enteral nutrition, can improve nutrient delivery to critically ill patients. Lipids provide a key source of calories within PN formulations, preventing or correcting energy deficits and improving outcomes.
2010 Apr - Greater cardiac response of colloid than saline fluid loading in septic and non-septic critically ill patients with clinical hypovolaemia
Trof RJ, Sukul SP, Twisk JW, Girbes AR, Groeneveld AB.; Intensive Care Med. 2010 Apr;36(4):697-701.
Background and objective
The haemodynamics of crystalloid and colloid fluid loading may depend on underlying disease, i.e. sepsis versus non-sepsis.
2010 Mar - Post-intubation laryngeal injuries and extubation failure: a fiberoptic endoscopic study
Tadié JM, Behm E, Lecuyer L, Benhmamed R, Hans S, Brasnu D, Diehl JL, Fagon JY, Guérot E.; Intensive Care Med. 2010 Mar 18. [Epub ahead of print]
PURPOSE: To describe laryngeal injuries after intubation in an intensive care unit and assess their risk factors and their association with post-extubation stridor (PES) and extubation failure.