2015 Jan - Effectiveness of treatment based on PiCCO parameters in critically ill patients with septic shock and/or acute respiratory distress syndrome: a randomized controlled trial

Zhang Z, Ni H, Qian Z.; Intensive Care Med. 2015 Jan 21. [Epub ahead of print]

Purpose: To compare treatment based on either PiCCO-derived physiological values or central venous pressure (CVP) monitoring, we performed a prospective randomized controlled trial with group sequential analysis.

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2014 Nov - Comparison of two repositioning schedules for the prevention of pressure ulcers in patients on mechanical ventilation with alternating pressure air mattresses

Manzano F, Colmenero M, Pérez-Pérez AM, Roldán D, Jiménez-Quintana Mdel M, Mañas MR, Sánchez-Moya MA, Guerrero C, Moral-Marfil MA, Sánchez-Cantalejo E, Fernández-Mondéjar E.; Intensive Care Med. 2014 Nov;40(11):1679-87.

PURPOSE: The objective was to compare the effectiveness of repositioning every 2 or 4 h for preventing pressure ulcer development in patients in intensive care unit under mechanical ventilation (MV).

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2014 Nov - Mechanisms of the effects of prone positioning in acute respiratory distress syndrome

Guerin C, Baboi L, Richard JC.; Intensive Care Med. 2014 Nov;40(11):1634-42

INTRODUCTION: Prone positioning has been used for many years in patients with acute respiratory distress syndrome (ARDS). The initial reason for prone positioning in ARDS patients was improvement in oxygenation. It was later shown that mechanical ventilation in the prone position can be less injurious to the lung and hence the primary reason to use prone positioning is prevention of ventilator-induced lung injury (VILI).

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2014 Nov - Surviving Sepsis Campaign: association between performance metrics and outcomes in a 7.5-year study

Levy MM, Rhodes A, Phillips GS, Townsend SR, Schorr CA, Beale R, Osborn T, Lemeshow S, Chiche JD, Artigas A, Dellinger RP.; Intensive Care Med. 2014 Nov;40(11):1623-33.

PURPOSE: To determine the association between compliance with the Surviving Sepsis Campaign (SSC) performance bundles and mortality.

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2014 Aug - Ten diseases you need to know if you want to be a critical care specialist in Hong Kong

Joynt GM, Tat WW.; Intensive Care Med. 2014 Aug;40(8):1144-6.

The Hong Kong Hospital Authority provides a high standard of intensive care for residents at nominal cost. The territory-wide mean predicted risk of hospital death by APACHE III-j score is 26 %, with a risk-adjusted hospital mortality of 0.8, and hospital median and mean length of stay 2.1 and 4.2 days [1]. While excellence in diagnosis and supportive care remain the cornerstone of ICU management internationally, practice in Hong Kong presents some special challenges.

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2014 Jul - Offering the opportunity for family to be present during cardiopulmonary resuscitation: 1-year assessment

Jabre P, Tazarourte K, Azoulay E, Borron SW, Belpomme V, Jacob L, Bertrand L, Lapostolle F, Combes X, Galinski M, Pinaud V, Destefano C, Normand D, Beltramini A, Assez N, Vivien B, Vicaut E, Adnet F.;  Intensive Care Med. 2014 Jul;40(7):981-7.

PURPOSE: To evaluate the psychological consequences among family members given the option to be present during the CPR of a relative, compared with those not routinely offered the option.

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2014 Jul - Helmet CPAP vs. oxygen therapy in severe hypoxemic respiratory failure due to pneumonia

Brambilla AM, Aliberti S, Prina E, Nicoli F, Forno MD, Nava S, Ferrari G, Corradi F, Pelosi P, Bignamini A, Tarsia P, Cosentini R.; Intensive Care Med. 2014 Jul;40(7):942-9.

PURPOSE: The efficacy of noninvasive continuous positive airway pressure (CPAP) to improve outcomes in severe hypoxemic acute respiratory failure (hARF) due to pneumonia has not been clearly established. The aim of this study was to compare CPAP vs. oxygen therapy to reduce the risk of meeting criteria for endotracheal intubation (ETI).

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2014 Jul - Capillary refill time exploration during septic shock

Ait-Oufella H, Bige N, Boelle PY, Pichereau C, Alves M, Bertinchamp R, Baudel JL, Galbois A, Maury E, Guidet B.;  Intensive Care Med. 2014 Jul;40(7):958-64

BACKGROUND: During septic shock management, the evaluation of microvascular perfusion by skin analysis is of interest. We aimed to study the skin capillary refill time (CRT) in a selected septic shock population.

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2014 Jul - Predictors of insufficient amikacin peak concentration in critically ill patients receiving a 25 mg/kg total body weight regimen

de Montmollin E, Bouadma L, Gault N, Mourvillier B, Mariotte E, Chemam S, Massias L, Papy E, Tubach F, Wolff M, Sonneville R.: Intensive Care Med. 2014 Jul;40(7):998-1005.

PURPOSE: Amikacin requires pharmacodynamic targets of peak serum concentration (C max) of 8-10 times the minimal inhibitory concentration, corresponding to a target C max of 60-80 mg/L for the less susceptible bacteria. Even with new dosing regimens of 25 mg/kg, 30 % of patients do not meet the pharmacodynamic target. We aimed to identify predictive factors for insufficient C max in a population of critically ill patients.

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2014 Jun - Intravenous administration of ulinastatin (human urinary trypsin inhibitor) in severe sepsis: a multicenter randomized controlled study

Karnad DR, Bhadade R, Verma PK, Moulick ND, Daga MK, Chafekar ND, Iyer S.;Intensive Care Med. 2014 Jun;40(6):830-8.

PURPOSE: Ulinastatin, a serine protease inhibitor, inhibits several pro-inflammatory proteases and decreases inflammatory cytokine levels and mortality in experimental sepsis. We studied the effect of ulinastatin on 28-day all-cause mortality in a double-blind trial in patients with severe sepsis in seven Indian hospitals.

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2014 Jun - What’s new in the clinical and diagnostic management of invasive candidiasis in critically ill patients

León C, Ostrosky-Zeichner L, Schuster M.; Intensive Care Med. 2014 Jun;40(6):808-19.

Invasive candidiasis (IC) is a severe complication in the ICU setting. A high proportion of ICU patients become colonized with Candida species, but only 5-30 % develop IC. Progressive colonization and major abdominal surgery are well-known risk factors for Candida infection. IC is difficult to predict and early diagnosis remains a major challenge.

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2014 Jun - Effects of interventions on survival in acute respiratory distress syndrome: an umbrella review of 159 published randomized trials and 29 meta-analyses

Tonelli AR, Zein J, Adams J, Ioannidis JP.; Intensive Care Med. 2014 Jun;40(6):769-87.

PURPOSE: Multiple interventions have been tested in acute respiratory distress syndrome (ARDS). We examined the entire agenda of published randomized controlled trials (RCTs) in ARDS that reported on mortality and of respective meta-analyses.

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2014 Mar - The impact of patient positioning on pressure ulcers in patients with severe ARDS: results from a multicentre randomised controlled trial on prone positioning

Girard R, Baboi L, Ayzac L, Richard JC, Guérin C; Proseva trial group.; Intensive Care Med. 2014 Mar;40(3):397-403.

PURPOSE: Placing patients with severe acute respiratory distress syndrome (ARDS) in the prone position has been shown to improve survival as compared to the supine position. However, a higher frequency of pressure ulcers has been reported in patients in the prone position. The objective of this study was to verify the impact of prone positioning on pressure ulcers in patients with severe ARDS.

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2014 Mar - Prone positioning reduces mortality from acute respiratory distress syndrome in the low tidal volume era: a meta-analysis

Beitler JR, Shaefi S, Montesi SB, Devlin A, Loring SH, Talmor D, Malhotra A.; Intensive Care Med. 2014 Mar;40(3):332-41.

PURPOSE: Prone positioning for ARDS has been performed for decades without definitive evidence of clinical benefit. A recent multicenter trial demonstrated for the first time significantly reduced mortality with prone positioning. This meta-analysis was performed to integrate these findings with existing literature and test whether differences in tidal volume explain conflicting results among randomized trials.

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2014 Jan - De-escalation of empirical therapy is associated with lower mortality in patients with severe sepsis and septic shock

Garnacho-Montero J, Gutiérrez-Pizarraya A, Escoresca-Ortega A, Corcia-Palomo Y, Fernández-Delgado E, Herrera-Melero I, Ortiz-Leyba C, Márquez-Vácaro JA.; Intensive Care Med. 2014 Jan;40(1):32-40.

PURPOSES: We set out to assess the safety and the impact on in-hospital and 90-day mortality of antibiotic de-escalation in patients admitted to the ICU with severe sepsis or septic shock.

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2014 Jan - Stress ulcer prophylaxis versus placebo or no prophylaxis in critically ill patients : A systematic review of randomised clinical trials with meta-analysis and trial sequential analysis

Krag M, Perner A, Wetterslev J, Wise MP, Hylander Møller M.; Intensive Care Med. 2014 Jan;40(1):11-22.

PURPOSE: To assess the effects of stress ulcer prophylaxis (SUP) versus placebo or no prophylaxis on all-cause mortality, gastrointestinal (GI) bleeding and hospital-acquired pneumonia in adult critically ill patients in the intensive care unit (ICU).

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2013 Nov - Impact of the humidification device on intubation rate during noninvasive ventilation with ICU ventilators: results of a multicenter randomized controlled trial.

Lellouche F, L'her E, Abroug F, Deye N, Rodriguez PO, Rabbat A, Jaber S, Fartoukh M, Conti G, Cracco C, Richard JC, Ricard JD, Mal H, Mentec H, Loisel F, Lacherade JC, Taillé S, Brochard L.; Intensive Care Med. 2013 Nov 26. [Epub ahead of print]

PURPOSE: The use of heat and moisture exchangers (HME) during noninvasive ventilation (NIV) can increase the work of breathing, decrease alveolar ventilation, and deliver less humidity in comparison with heated humidifiers (HH). We tested the hypothesis that the use of HH during NIV with ICU ventilators for patients with acute respiratory failure would decrease the rate of intubation (primary endpoint) as compared with HME.

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2013 Nov - Palliative care in the ICU: relief of pain, dyspnea, and thirst-A report from the IPAL-ICU Advisory Board

Puntillo K, Nelson JE, Weissman D, Curtis R, Weiss S, Frontera J, Gabriel M, Hays R, Lustbader D, Mosenthal A, Mulkerin C, Ray D, Bassett R, Boss R, Brasel K, Campbell M.; Intensive Care Med. 2013 Nov 26. [Epub ahead of print]

PURPOSE: Pain, dyspnea, and thirst are three of the most prevalent, intense, and distressing symptoms of intensive care unit (ICU) patients. In this report, the interdisciplinary Advisory Board of the Improving Palliative Care in the ICU (IPAL-ICU) Project brings together expertise in both critical care and palliative care along with current information to address challenges in assessment and management.

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2013 Nov - Lack of association between body weight and mortality in patients on veno-venous extracorporeal membrane oxygenation

Al-Soufi S, Buscher H, Nguyen ND, Rycus P, Nair P.; Intensive Care Med. 2013 Nov;39(11):1995-2002.

PURPOSE: To analyse the association of body weight with hospital mortality of adult patients supported with veno-venous extracorporeal membrane oxygenation (VV ECMO).

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2013 Nov - Intensive care unit mortality after cardiac arrest: the relative contribution of shock and brain injury in a large cohort

Lemiale V, Dumas F, Mongardon N, Giovanetti O, Charpentier J, Chiche JD, Carli P, Mira JP, Nolan J, Cariou A.; Intensive Care Med. 2013 Nov;39(11):1972-1980.

OBJECTIVE: Brain injury is well established as a cause of early mortality after out-of-hospital cardiac arrest (OHCA), but postresuscitation shock also contributes to these deaths. This study aims to describe the respective incidence, risk factors, and relation to mortality of post-cardiac arrest (CA) shock and brain injury.

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