2013 Nov - Ultrasound-guided central venous cannulation is superior to quick-look ultrasound and landmark methods among inexperienced operators: a prospective randomized study

Airapetian N, Maizel J, Langelle F, Modeliar SS, Karakitsos D, Dupont H, Slama M.; Intensive Care Med. 2013 Nov;39(11):1938-1944.

OBJECTIVE: Quick-look ultrasound with a skin mark (UM) has been frequently used for central vein cannulation. The aim of this study is to compare this method with landmark (LM) and ultrasound-guided (UG) cannulation of jugular and femoral veins by inexperienced operators.

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2013 Nov - Safety of off-label erythropoiesis stimulating agents in critically ill patients: a meta-analysis

Mesgarpour B, Heidinger BH, Schwameis M, Kienbacher C, Walsh C, Schmitz S, Herkner H.; Intensive Care Med. 2013 Nov;39(11):1896-1908.

PURPOSE: Erythropoiesis stimulating agents (ESAs) are used to treat anemia in critically ill patients. This indication is off-label, because it is not licensed by regulatory authorities. Recently ESAs were suspected to harm critically ill patients. Our objective was to assess the safety of ESAs in off-label indications in critically ill patients.

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2013 Nov - Managing the apparent and hidden difficulties of weaning from mechanical ventilation

Perren A, Brochard L.; Intensive Care Med. 2013 Nov;39(11):1885-1895.

BACKGROUND: In anaesthetized patients scheduled for surgery, tracheal intubation is performed with the expectation of subsequent smooth extubation. In critically ill patients, separation from the ventilator is often gradual and the time chosen for extubation may be either delayed or premature. Thus, weaning is challenging, represents a large part of the ventilation period and concerns all mechanically ventilated patients surviving their stay.

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2013 Sep - De-escalation of empirical therapy is associated with lower mortality in patients with severe sepsis and septic shock

Garnacho-Montero J, Gutiérrez-Pizarraya A, Escoresca-Ortega A, Corcia-Palomo Y, Fernández-Delgado E, Herrera-Melero I, Ortiz-Leyba C, Márquez-Vácaro JA.; Intensive Care Med. 2013 Sep 12. [Epub ahead of print]

PURPOSES: We set out to assess the safety and the impact on in-hospital and 90-day mortality of antibiotic de-escalation in patients admitted to the ICU with severe sepsis or septic shock.

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2013 Sep - Pre-emptive broad-spectrum treatment for ventilator-associated pneumonia in high-risk patients

Bouza E, Granda MJ, Hortal J, Barrio JM, Cercenado E, Muñoz P.; Intensive Care Med. 2013 Sep;39(9):1547-55.

PURPOSE: Patients requiring mechanical ventilation (MV) for >48 h after major heart surgery (MHS) are at a high risk of acquiring ventilator-associated pneumonia (VAP) and tracheobronchitis (VAT). Most non-pharmacological interventions to prevent VAP in such patients are usually already implemented. The objective of this study was to evaluate the efficacy in preventing lower respiratory infections of antibiotics active against multidrug-resistant pathogens in this very high-risk population.

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2013 Sep - Debriefing to improve outcomes from critical illness: a systematic review and meta-analysis

Couper K, Salman B, Soar J, Finn J, Perkins GD.; Intensive Care Med. 2013 Sep;39(9):1513-23.

PURPOSE: Intensive care clinicians play a central role in the co-ordination and treatment of patients that develop life-threatening emergencies. This review evaluates the effect of debriefing after life-threatening emergencies and considers the implications for intensive care training and practice.

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2013 Jun - Prognostication of neurologic outcome in cardiac arrest patients after mild therapeutic hypothermia: a meta-analysis of the current literature

Kamps MJ, Horn J, Oddo M, Fugate JE, Storm C, Cronberg T, Wijman CA, Wu O, Binnekade JM, Hoedemaekers CW.; Intensive Care Med. 2013 Jun 26. [Epub ahead of print]

PURPOSE: To assess the sensitivity and false positive rate (FPR) of neurological examination and somatosensory evoked potentials (SSEPs) to predict poor outcome in adult patients treated with therapeutic hypothermia after cardiopulmonary resuscitation (CPR).

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2013 Aug - Effects of dobutamine on systemic, regional and microcirculatory perfusion parameters in septic shock: a randomized, placebo-controlled, double-blind, crossover study

Hernandez G, Bruhn A, Luengo C, Regueira T, Kattan E, Fuentealba A, Florez J, Castro R, Aquevedo A, Pairumani R, McNab P, Ince C.; Intensive Care Med. 2013 Aug;39(8):1435-43.

PURPOSE: The role of dobutamine during septic shock resuscitation is still controversial since most clinical studies have been uncontrolled and no physiological study has unequivocally demonstrated a beneficial effect on tissue perfusion. Our objective was to determine the potential benefits of dobutamine on hemodynamic, metabolic, peripheral, hepatosplanchnic and microcirculatory perfusion parameters during early septic shock resuscitation.

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2013 Aug - Half-molar sodium lactate infusion to prevent intracranial hypertensive episodes in severe traumatic brain injured patients: a randomized controlled trial

Ichai C, Payen JF, Orban JC, Quintard H, Roth H, Legrand R, Francony G, Leverve XM.; Intensive Care Med. 2013 Aug;39(8):1413-22.

PURPOSE: Preventive treatments of traumatic intracranial hypertension are not yet established. We aimed to compare the efficiency of half-molar sodium lactate (SL) versus saline serum solutions in preventing episodes of raised intracranial pressure (ICP) in patients with severe traumatic brain injury (TBI).

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2013 Aug - Time to reach a new steady state after changes of positive end expiratory pressure

Chiumello D, Coppola S, Froio S, Mietto C, Brazzi L, Carlesso E, Gattinoni L.; Intensive Care Med. 2013 Aug;39(8):1377-85.

PURPOSE: To assess the time interval required to reach a new steady state of oxygenation-, ventilation-, respiratory mechanics- and hemodynamics-related variables after decreasing/increasing positive end expiratory pressure (PEEP).

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2013 Aug - Risk factors and impact of major bleeding in critically ill patients receiving heparin thromboprophylaxis

Lauzier F, Arnold DM, Rabbat C, Heels-Ansdell D, Zarychanski R, Dodek P, Ashley BJ, Albert M, Khwaja K, Ostermann M, Skrobik Y, Fowler R, McIntyre L, Nates JL, Karachi T, Lopes RD, Zytaruk N, Finfer S, Crowther M, Cook D.; Intensive Care Med. 2013 Aug 14. [Epub ahead of print]

PURPOSE: Bleeding frequently complicates critical illness and may have serious consequences. Our objectives are to describe the predictors of major bleeding and the association between bleeding and mortality in medical-surgical critically ill patients receiving heparin thromboprophylaxis.

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2013 Jul - Clinical impact of arterial ammonia levels in ICU patients with different liver diseases

Drolz A, Jäger B, Wewalka M, Saxa R, Horvatits T, Roedl K, Perkmann T, Zauner C, Kramer L, Ferenci P, Fuhrmann V.; Intensive Care Med. 2013 Jul;39(7):1227-37.

PURPOSE: Increased arterial ammonia levels are associated with high mortality in patients with acute liver failure (ALF). Data on the prognostic impact of arterial ammonia is lacking in hypoxic hepatitis (HH) and scarce in critically ill patients with cirrhosis.

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2013 Jul - Intra-abdominal hypertension and the abdominal compartment syndrome: updated consensus definitions and clinical practice guidelines from the World Society of the Abdominal Compartment Syndrome

Kirkpatrick AW, Roberts DJ, De Waele J, Jaeschke R, Malbrain ML, De Keulenaer B, Duchesne J, Bjorck M, Leppaniemi A, Ejike JC, Sugrue M, Cheatham M, Ivatury R, Ball CG, Reintam Blaser A, Regli A, Balogh ZJ, D'Amours S, Debergh D, Kaplan M, Kimball E, Olvera C; Pediatric Guidelines Sub-Committee for the World Society of the Abdominal Compartment Syndrome.; Intensive Care Med. 2013 Jul;39(7):1190-206.

PURPOSE: To update the World Society of the Abdominal Compartment Syndrome (WSACS) consensus definitions and management statements relating to intra-abdominal hypertension (IAH) and the abdominal compartment syndrome (ACS).

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2013 Jul - Noninvasive ventilation in chest trauma: systematic review and meta-analysis

Chiumello D, Coppola S, Froio S, Gregoretti C, Consonni D.; Intensive Care Med. 2013 Jul;39(7):1171-80.

PURPOSE: Single studies of Noninvasive Ventilation (NIV) in the management of acute respiratory failure in chest trauma patients have produced controversial findings. The aim of this study is to critically review the literature to investigate whether NIV reduces mortality, intubation rate, length of stay and complications in patients with chest trauma, compared to standard therapy.

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2013 Jun - Central venous-arterial pCO2 difference as a tool in resuscitation of septic patients

van Beest PA, Lont MC, Holman ND, Loef B, Kuiper MA, Boerma EC.; Intensive Care Med. 2013 Jun;39(6):1034-9.

PURPOSE: To investigate the interchangeability of mixed and central venous-arterial carbon dioxide differences and the relation between the central difference (pCO2 gap) and cardiac index (CI). We also investigated the value of the pCO2 gap in outcome prediction.

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2013 May - Recommendations on the use of EEG monitoring in critically ill patients: consensus statement from the neurointensive care section of the ESICM

Claassen J, Taccone FS, Horn P, Holtkamp M, Stocchetti N, Oddo M.; Intensive Care Med. 2013 May 8. [Epub ahead of print]

OBJECTIVES: Recommendations for EEG monitoring in the ICU are lacking. The Neurointensive Care Section of the ESICM assembled a multidisciplinary group to establish consensus recommendations on the use of EEG in the ICU.

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2013 Jun - Number of supervised studies required to reach competence in advanced critical care transesophageal echocardiography

Charron C, Vignon P, Prat G, Tonnelier A, Aegerter P, Boles JM, Amiel JB, Vieillard-Baron A.; Intensive Care Med. 2013 Jun;39(6):1019-24.

PURPOSE: To determine the minimum number of supervised transesophageal echocardiography (TEE) that intensivists should perform to reach competence in performing and interpreting a comprehensive hemodynamic assessment in ventilated intensive care unit patients.

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2013 Jun - Choice of renal replacement therapy modality and dialysis dependence after acute kidney injury: a systematic review and meta-analysis

Schneider AG, Bellomo R, Bagshaw SM, Glassford NJ, Lo S, Jun M, Cass A, Gallagher M.; Intensive Care Med. 2013 Jun;39(6):987-97.

PURPOSE: Choice of renal replacement therapy (RRT) modality may affect renal recovery after acute kidney injury (AKI). We sought to compare the rate of dialysis dependence among severe AKI survivors according to the choice of initial renal replacement therapy (RRT) modality applied [continuous (CRRT) or intermittent (IRRT)].

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2013 Jun - The effects of increasing effective airway diameter on weaning from mechanical ventilation in tracheostomized patients: a randomized controlled trial

Hernandez G, Pedrosa A, Ortiz R, Cruz Accuaroni Mdel M, Cuena R, Vaquero Collado C, García Plaza S, González Arenas P, Fernandez R.; Intensive Care Med. 2013 Jun;39(6):1063-70.

PURPOSE: To determine the effects of deflating the tracheal cuff during disconnections from mechanical ventilation (MV) in tracheostomized patients.

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2013 May - Sedation depth and long-term mortality in mechanically ventilated critically ill adults: a prospective longitudinal multicentre cohort study

Shehabi Y, Chan L, Kadiman S, Alias A, Ismail WN, Tan MA, Khoo TM, Ali SB, Saman MA, Shaltut A, Tan CC, Yong CY, Bailey M; Sedation Practice in Intensive Care Evaluation (SPICE) Study Group investigators.; Intensive Care Med. 2013 May;39(5):910-8

PURPOSE: To ascertain the relationship among early (first 48 h) deep sedation, time to extubation, delirium and long-term mortality.

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